Maternal Tolerance to the Allogeneic Fetus in Antigen-Hyporesponsive T Cells Induces Adoptive Transfer of Paternal

Abortion-Prone Matings Maternal Tolerance to the Allogeneic Fetus in Antigen-Hyporesponsive T Cells Induces Adoptive Transfer of Paternal

A link between PDL1 and T regulatory cells in fetomaternal tolerance.

Acceptance of the fetus expressing allogeneic paternal Ags by the mother is a physiologic model of transplantation tolerance. Various mechanisms contribute to fetal evasion from immune attack by maternal leukocytes. We have recently demonstrated that the inhibitory costimulatory molecule PDL1 plays a critical role in fetomaternal tolerance in that PDL1 blockade or deficiency resulted in decreas...

P-154: Comparison between The Effect of 17-Bestradiol at Preovulatory and Pregnancy Levels for In Vitro Generation of Regulatory T Cells

Background: Naturally occurring CD4+CD25+ regulatory T cells (Treg) exert an important role in mediating maternal tolerance to the fetus during pregnancy. During pregnancy the elevated number of regulatory T cells (Tregs) correlates with 17-b oestradiol (E2) level. The role of maternal hormones in successful pregnancy is well known. Maternal hormones through re-engineering of the maternal immun...

Paternal Antigen-Bearing Cells Transferred

Maternal immunological tolerance of the semiallogeneic fetus involves several overlapping mechanisms to balance maternal immunity and fetal development. Anti-paternal CD8 ؉ T cells are suppressed during pregnancy in some but not all mouse models. Since semen has been shown to mediate immune modulation, we tested whether exposure to paternal Ag during insemination activated or tolerized anti-pat...

The "Miracle" fetus: an excellent model for apoptotic cell-induced immune tolerance?

For several decades, people have wondered why pregnant mothers do not reject fetuses bearing allogeneic paternal antigens. Several hypotheses have been proposed, including a physical barrier between fetus and mother, immaturity of fetal antigens and temporary dormancy of the maternal immune system. Based on the "cell death immune recognition model," the author proposes a hypothesis that pregnan...